GuidesJanuary 26, 2026•4 min read

Getting Started with Peptides: A Beginner's Guide

Everything you need to know before exploring research peptides - terminology, categories, safety considerations, and how to use this guide effectively.

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Introduction

Peptides are short chains of amino acids that serve as building blocks for proteins. In research and clinical settings, synthetic peptides have gained significant attention for their potential therapeutic applications. This guide provides a foundation for understanding peptides and how to use PepGuide effectively.

What Are Peptides?

Peptides are molecules consisting of two or more amino acids linked by peptide bonds. While proteins typically contain 50+ amino acids, peptides are generally shorter chains:

  • Dipeptides: 2 amino acids
  • Tripeptides: 3 amino acids
  • Oligopeptides: 2-20 amino acids
  • Polypeptides: 20-50 amino acids

Many research peptides fall into the oligopeptide category, making them small enough to be synthesized in laboratories while still maintaining biological activity.

Categories of Research Peptides

Research peptides are often categorized by their primary function or mechanism:

Growth Hormone Secretagogues

These peptides stimulate the body's natural production of growth hormone. Examples include:

  • Ipamorelin - Selective GH release with minimal side effects
  • CJC-1295 - Extended GH-releasing hormone analog
  • GHRP-6 - Potent GH release with appetite stimulation

Healing & Recovery

Peptides that support tissue repair and regeneration:

  • BPC-157 - Gastric pentadecapeptide with broad healing properties
  • TB-500 - Thymosin beta-4 fragment for tissue repair
  • GHK-Cu - Copper peptide for skin and tissue regeneration

Metabolic & Weight Management

Peptides affecting metabolism and body composition:

  • Semaglutide - GLP-1 agonist for metabolic regulation
  • Tirzepatide - Dual GIP/GLP-1 agonist
  • 5-Amino-1MQ - NNMT inhibitor for metabolic support

Cognitive & Neuroprotective

Peptides with potential cognitive benefits:

  • Semax - Nootropic peptide derived from ACTH
  • Selank - Anxiolytic peptide with cognitive effects
  • Dihexa - Potent cognitive-enhancing peptide

Understanding Dosing Information

When reviewing peptide information on PepGuide, you'll encounter several key terms:

Dosing Range

The typical range of doses used in research settings. This is not a recommendation but rather a reference point based on published literature.

Frequency

How often the peptide is typically administered:

  • Daily - Once per day
  • BID - Twice daily
  • EOD - Every other day
  • Weekly - Once per week

Half-Life

The time it takes for half of the peptide to be eliminated from the system. This influences dosing frequency:

  • Short half-life (minutes to hours) = more frequent dosing
  • Long half-life (days) = less frequent dosing

Safety Considerations

Important: Research peptides are not approved for human use by the FDA. The information on PepGuide is for educational purposes only. Always consult with a qualified healthcare provider.

Key Safety Principles

  1. Start Low, Go Slow - Research protocols typically begin with lower doses
  2. Quality Matters - Source and purity significantly impact outcomes
  3. Storage is Critical - Most peptides require refrigeration after reconstitution
  4. Monitor and Document - Tracking responses helps identify issues early

Reconstitution Basics

Most research peptides come as lyophilized (freeze-dried) powder and require reconstitution:

  1. Use bacteriostatic water (BAC water) for multi-use
  2. Add water slowly along the vial wall
  3. Gently swirl - never shake
  4. Store reconstituted peptides refrigerated
  5. Use within 30-60 days after reconstitution

How to Use PepGuide

Peptide Profiles

Each peptide entry includes:

  • Overview - General description and key characteristics
  • Mechanism - How the peptide works
  • Research - Summary of scientific studies
  • Dosing - Typical research protocols
  • Safety - Known considerations and contraindications
  • References - Scientific literature citations

Comparison Tool

Use the Compare Tool to view peptides side-by-side. This is helpful when:

  • Evaluating similar peptides in a category
  • Understanding differences in dosing and frequency
  • Comparing safety profiles

Dosing Calculator

The Calculator helps with reconstitution math:

  • Determine concentration after adding water
  • Calculate volume needed for specific doses
  • Avoid common math errors

Next Steps

Now that you understand the basics:

  1. Explore by Category - Browse the Peptides section
  2. Read Individual Profiles - Deep dive into specific peptides
  3. Use the Tools - Try the calculator and comparison features
  4. Stay Updated - New content is added regularly

Conclusion

Peptides represent a fascinating area of research with diverse potential applications. Whether you're a researcher, student, or curious learner, understanding the fundamentals helps you navigate this complex field safely and effectively.

Remember: This guide is for educational purposes. Always prioritize safety and consult qualified professionals for any health-related decisions.