GHRP-6

Overview

GHRP-6 (Growth Hormone Releasing Peptide-6) is a first-generation synthetic hexapeptide that stimulates growth hormone release through the ghrelin receptor. Developed in the 1980s, it was one of the first peptides discovered to have GH-releasing properties.

GHRP-6 is distinguished from other GHRPs by its potent appetite stimulation - it causes significant hunger increases that some users find beneficial (for bulking) while others find problematic.

Key Characteristics

• Origin: Synthetic hexapeptide (6 amino acids)
• Classification: First-generation GHRP, Ghrelin receptor agonist
• Sequence: His-D-Trp-Ala-Trp-D-Phe-Lys-NH2
• Distinguishing Feature: Strong appetite stimulation
• GH Release: Potent, but less selective than newer GHRPs

The GHRP Family Comparison

| GHRP | Generation | Appetite | Cortisol | Prolactin | Selectivity | |------|------------|----------|----------|-----------|-------------| | GHRP-6 | 1st | +++++ | ++ | ++ | Low | | GHRP-2 | 2nd | +++ | ++ | ++ | Medium | | Ipamorelin | 3rd | + | - | - | High |

GHRP-6 is the least selective but one of the most potent for raw GH release.

Mechanism

Primary Mechanisms

1. Ghrelin Receptor Activation (GHS-R1a)

GHRP-6 is a potent ghrelin mimetic:

• Binds strongly to growth hormone secretagogue receptor
• Triggers GH release from pituitary
• Mimics the "hunger hormone" ghrelin
• Creates both GH and appetite effects

2. Appetite Stimulation

The hunger effect is significant:

• Ghrelin receptor activation in hypothalamus
• Stimulates NPY/AgRP neurons
• Creates intense hunger within 20-30 minutes
• Effects can last several hours
• Much stronger than GHRP-2 or ipamorelin

3. Cortisol and Prolactin Increase

Unlike ipamorelin, GHRP-6 affects other hormones:

• Modest cortisol elevation
• Modest prolactin elevation
• Effects are dose-dependent
• Usually not clinically significant at normal doses

4. Somatostatin Suppression

As a GHRP:

• Inhibits somatostatin (the "GH brake")
• Allows greater GH release
• Synergizes with GHRH analogs
• Creates amplified GH pulse

Research

Growth Hormone Release

Clinical Studies

Research demonstrates:

• Potent dose-dependent GH release
• Peak GH levels 30-60 minutes post-injection
• Greater magnitude than ipamorelin
• Consistent response with repeated use

Appetite and Weight Gain

Ghrelin Mimetic Effects

Studies show:

• Significant increase in food intake
• Useful for those struggling to eat enough
• Can help with weight gain goals
• May benefit cachexia patients

Muscle and Body Composition

Anabolic Potential

Research indicates:

• Increased lean body mass
• Improved nitrogen retention
• Enhanced recovery
• Potential strength gains

Gastric Motility

GI Effects

Like ghrelin, GHRP-6:

• Increases gastric emptying
• Enhances gut motility
• May help post-operative ileus
• Promotes digestive function

Cardioprotective Research

Emerging Area

Some studies suggest:

• Potential heart-protective effects
• Reduced cardiac damage in ischemia models
• May improve cardiac function
• Needs more human research

Dosing

Research Protocols

Administration Notes

Timing Considerations

• Dose 15-30 minutes before meals (use hunger productively)
• OR dose at bedtime for GH pulse without food distraction
• Fasted state enhances GH release
• Eating blunts GH but satisfies hunger

The Saturation Dose

• 1 mcg/kg appears to be saturation point
• ~100 mcg for average person
• Higher doses don't proportionally increase GH
• But DO increase appetite and side effects

Managing the Hunger For those who don't want extreme appetite:

• Use lower doses (100 mcg)
• Dose before planned meals
• Consider switching to ipamorelin
• Avoid GHRP-6 if dieting

Reconstitution

• Use bacteriostatic water
• Standard: 5mg vial + 2.5ml water = 2mg/ml
• Refrigerate after reconstitution
• Stable for 4-6 weeks
• Avoid freezing

Synergy & Stacking

The GHRH + GHRP Principle

Maximum GH Release

Combining GHRH analog with GHRP creates synergy:

• GHRP (GHRP-6) releases the "brake" (somatostatin)
• GHRH (CJC-1295, Sermorelin) presses the "accelerator"
• Combined effect is multiplicative
• 3-10x greater GH release than either alone

Common Combinations

GHRP-6 + CJC-1295 (No DAC)

Classic bulking stack:

• 100-200 mcg GHRP-6
• 100-200 mcg CJC-1295
• 2-3x daily
• Strong GH release + strong appetite = growth

GHRP-6 + Sermorelin

Traditional combination:

• Both well-established
• Strong GH pulse
• Lower cost option
• Effective for mass gaining

When GHRP-6 is Preferred

Choose GHRP-6 over ipamorelin when:

• Appetite stimulation is desired
• Weight gain is the goal
• Struggling to eat enough
• Maximum GH release wanted

When to Choose Other GHRPs

Choose ipamorelin instead when:

• Dieting or cutting
• Appetite increase unwanted
• Wanting "cleaner" profile
• Concerned about cortisol/prolactin

Safety

Known Side Effects

Common

• Intense hunger (primary effect, not "side" effect)
• Water retention (dose-dependent)
• Lethargy/tiredness
• Headache (usually temporary)
• Dizziness

Less Common

• Tingling/numbness (carpal tunnel-like)
• Flushing
• Joint aches
• Increased cortisol (usually mild)
• Elevated prolactin (usually mild)

Compared to Ipamorelin

• More water retention
• More appetite stimulation
• More cortisol/prolactin effects
• More side effects overall

Contraindications

Avoid or use with extreme caution if:

• Active cancer or cancer history
• Diabetic (glucose effects possible)
• Trying to lose weight
• History of compulsive eating
• Pregnancy or breastfeeding

Drug Interactions

• May affect glucose metabolism
• Potential interaction with diabetes medications
• Generally safe with most common medications
• Caution with corticosteroids

Monitoring

Baseline Assessments

• IGF-1 level
• Fasting glucose
• Prolactin (optional)
• Body weight and composition

During Use

• IGF-1 (every 3-6 months)
• Weight monitoring
• Appetite tracking
• Side effect assessment
• Glucose if diabetic

Signs of Excessive Use

• Significant water retention
• Carpal tunnel symptoms
• Persistent fatigue
• Elevated prolactin symptoms

Regulatory

Current Status

| Region | Status | |--------|--------| | United States | Not FDA-approved; research chemical | | WADA | Strictly Prohibited (S2 category) | | Detection | Easily detectable for days post-use | | Availability | Research chemical suppliers |

Legal Considerations

• Available as research chemical
• Not approved for human therapeutic use
• Athletes: Strictly banned
• Quality varies by supplier

Clinical Outlook

GHRP-6's place in peptide landscape:

• Largely superseded by ipamorelin for most uses
• Remains popular for those wanting appetite stimulation
• Useful for weight gain protocols
• Less expensive than newer alternatives
• Still effective for GH release

References